US-Flexalign is the first universal platform for the flexible structure alignment of both proteins and RNAs under a unified TM-score scoring framework. To accommodate large conformational changes, it performs incremental rigid-body alignment of individual folding units and extends this procedure with an AFP-based strategy for robust residue correspondence identification. Compared with existing flexible alignment programs, US-Flexalign achieves substantially faster execution speed while consistently improving alignment accuracy, providing an efficient and practical solution for large-scale macromolecular structural comparison.
US-Flexalign online webserver
Flexible alignment of a pair of monomers, allowing multiple hinges (US-Flexalign). [View protein example] [View RNA example]
Download(s)
- Click USFlexalign.cpp
to download the single-file C++ source code of US-Flexalign.
You can compile the program in your Linux computer by
-
$ g++ -static -O3 -ffast-math -o USFlexalign USFlexalign.cpp
- Click FlexBench.zip to download the benchmark dataset.
Reference(s)
- Yunchi Zhu, Shizhao Yan, Xi Zhang, Yang Zhang, Chengxin Zhang, US-Flexalign: a unified platform for flexible structure alignment of proteins and RNAs, In preparation.